| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763893 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Curcumin inhibits CD4+ T-lymphocyte proliferation. ⺠Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4+ T-lymphocytes. ⺠Curcumin interferes with IL-2 receptor signaling by inhibiting JAK3 and STAT5 phosphorylation. ⺠IL-2-dependent regulatory T-lymphocyte function and Foxp3 expression is downregulated by curcumin.
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Authors
Nicholas A. Forward, David M. Conrad, Melanie R. Power Coombs, Carolyn D. Doucette, Suzanne J. Furlong, Tong-Jun Lin, David W. Hoskin,