| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763921 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The AMP-activated protein kinase (AMPK) down-regulates the inward rectifier K+ channel Kir2.1. ⺠Kir2.1 is similarly down-regulated by constitutively active γR70QAMPK but not by inactive mutant αK45RAMPK. ⺠AMPK decreases the Kir2.1 protein abundance in the cell membrane. ⺠Kir2.1 is down-regulated by the ubiquitin ligase Nedd4-2. ⺠AMPK augments the effect of wild type Nedd4-2 but not of Nedd4-2S795A lacking the AMPK phosphorylation site.
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Authors
Ioana Alesutan, Carlos Munoz, Mentor Sopjani, Miribane Dërmaku-Sopjani, Diana Michael, Scott Fraser, Bruce E. Kemp, Guiscard Seebohm, Michael Föller, Florian Lang,