Phosphatidylinositol 5-phosphate 4-kinase type II beta is required for vitamin D receptor-dependent E-cadherin expression in SW480 cells

Article ID	Journal	Published Year	Pages	File Type
10763924	Biochemical and Biophysical Research Communications	2011	7 Pages	PDF

Abstract

âº We analyzed Phosphatidylinositol 5-phosphate kinase IIÎ² (PIPKIIÎ²) function in cancer. âº PIPKIIÎ² is required for vitamin D receptor-mediated E-cadherin upregulation in SW480. âº PIPKIIÎ² suppresses cellular motility through E-cadherin induction in SW480 cells. âº Nuclear PIP2 but not plasma membrane-localized PIP2 mediates E-cadherin upregulation.

Keywords

eGFP qRT-PCR PDZ VDR SW480 Cellular motility 1α,25(OH)2D3 1α,25-dihydroxyvitamin D3 E-cadherin PI(4,5)P2 phosphatidylinositol 4,5-bisphosphate enhanced green fluorescent protein PIP kinase Vitamin D receptor