| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763930 | Biochemical and Biophysical Research Communications | 2011 | 4 Pages |
Abstract
⺠FKBPs are cellular receptors for the immunosuppressant FK506 and anti-cancer agent rapamycin. ⺠FKBP23, a calcium-binding chaperone, acts as a trigger factor in regulating the ATPase activity of BiP. ⺠We found Pro117 in the ATPase domain of BiP was the target site for FKBP23. ⺠This regulatory mechanism is completely different from all of the well-known regulatory systems. ⺠We are the first to combine PPIase activity on peptides with that on the full-length substrate proteins.
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Authors
Miao Feng, Chao Gu, Shikui Ma, Ying Wang, Huijuan Liu, Ruifang Han, Junfei Gao, Yi Long, Huaifeng Mi,