| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763931 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Identification of a conserved BH3 motif in C-terminal coiled coil region of nCLU. ⺠The nCLU BH3 domain binds to BH3 peptide-binding grooves in both Bcl-XL and Bcl-2. ⺠A conserved binding mechanism of nCLU BH3 and the other pro-apoptotic BH3 peptides with Bcl-XL. ⺠The absolutely conserved Leu323 and Asp328 of nCLU BH3 domain are critical for binding to Bcl-XL. ⺠Molecular understanding of the pro-apoptotic function of nCLU as a novel BH3-only protein.
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Authors
Dong-Hwa Lee, Ji-Hyang Ha, Yul Kim, Kwang-Hee Bae, Jae-Yong Park, Wan Sung Choi, Ho Sup Yoon, Sung Goo Park, Byoung Chul Park, Gwan-Su Yi, Seung-Wook Chi,