| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763947 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Neurodegeneration in AMSH-deficient mice occurs by the ubiquitinated aggregates. ⺠Distribution of the aggregates is restricted in CA1, and not in CA3. ⺠Glutamate receptors and p62 colocalizes with the aggregates. ⺠TDP-43 is accumulated in glial cells. ⺠AMSH is required for autophagic clearance of aggregate-prone proteins.
Keywords
associated molecule with the SH3 domain of STAMAMPARFTDDUBCHMPNMDARMVBESCRTdeubiquitinating enzymeamyotrophic lateral sclerosisAMshmultivesicular bodyAlzheimer’s diseaseALSParkinson’s diseaseNeurodegenerationfrontotemporal dementiaendosomal sorting complexes required for transportHippocampusN-methyl-d-aspartate receptorUbiquitin
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Authors
Shunya Suzuki, Keiichi Tamai, Masahiko Watanabe, Masanao Kyuuma, Masao Ono, Kazuo Sugamura, Nobuyuki Tanaka,