| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10763951 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Promoter hypermethylation of BRCA1 was only detected in three samples of infiltrating carcinoma. ⺠Hypermethylation of ERCC1, XRCC1, and MLH1 was found to increase gradually throughout lung carcinogenesis progression. ⺠BRCA1 and MLH1 protein expression decreased progressively during lung carcinogenesis, whereas ERCC1 and XRCC1 expression were only found in later stages. ⺠An inverse correlation between methylation status and protein expression was found for BRCA1 and MLH1.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Wen-bin Liu, Lin Ao, Zhi-hong Cui, Zi-yuan Zhou, Yan-hong Zhou, Xiao-yan Yuan, Yun-long Xiang, Jia Cao, Jin-yi Liu,