Article ID Journal Published Year Pages File Type
10763956 Biochemical and Biophysical Research Communications 2011 6 Pages PDF
Abstract
► Monothiol glutaredoxin Grx4 allows Fep1-mediated de-repression of iron uptake genes at low iron. ► Grx4 directly interacts with Fep1 in vivo and in vitro. ► The Cys172 in the CGFS motif of Grx4 is necessary for cell proliferation and iron regulation. ► The Cys172 of Grx4 is required for normal interaction with Fep1.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast
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