Circadian rhythm of cholesterol synthesis in mouse liver: A statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice

Article ID	Journal	Published Year	Pages	File Type
10763978	Biochemical and Biophysical Research Communications	2011	7 Pages	PDF

Abstract

âº Cholesterol synthesis in mouse liver follows a circadian rhythm. âº Females have higher levels of cholesterol and post-squalene precursors than males. âº Phase differences in Crem-knock-out mice are only significant for dihydrolanosterol.

Keywords

7-Dehydrocholesterol WTM cAMP response element modulator FF-MAS T-MAS DHL WTF SREBPs ICER CYP51 7-DHC GC–MS Cosinor analysis Multiple regression Circadian rhythm Zeitgeber time Inducible cAMP early repressor Cholesterol synthesis gas chromatography–mass spectrometry Cres CREm

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Circadian rhythm of cholesterol synthesis in mouse liver: A statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice

Authors

Jure AÄimoviÄ, Rok KoÅ¡ir, Damijana Kastelec, Martina PerÅ¡e, Gregor MajdiÄ, Damjana Rozman, Katarina KoÅ¡melj, Marko GoliÄnik,