Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10763995 | Biochemical and Biophysical Research Communications | 2011 | 5 Pages |
Abstract
⺠Nek6 inhibits premature senescence after CPT and DOX treatment in EJ and H1299 cells. ⺠DOX-induced G2/M arrest was inhibited by Nek6 overexpression. ⺠The reduction in cyclin B and cdc2 levels after DOX treatment were reduced by Nek6. ⺠The increase in intracellular ROS levels after DOX treatment was inhibited by Nek6. ⺠Nek6 may play a role in tumorigenesis by inhibiting premature senescence.
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Authors
Hye Jin Jee, Hyun-Ju Kim, Ae Jeong Kim, Naree Song, Minjee Kim, Jeanho Yun,