Article ID Journal Published Year Pages File Type
10764031 Biochemical and Biophysical Research Communications 2010 6 Pages PDF
Abstract
► Identification of a mutation that affects reactivity of the Orp1 thiol peroxidase towards non-polar peroxides, but not hydrogen peroxide. ► Identification of two conserved amino acids that when mutated, decrease the peroxidase activity of the Orp1 thiol peroxidase. ► Formation of a cysteine sulfenic acid intermediate on the Orp1 thiol peroxidase in response to cumene and tert-butyl hydroperoxide.
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