| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764042 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠Deoxy-ribonucleotide triphosphates (dNTPs) are better cosubstrates than ribonucleotide triphosphates (NTPs) for ANT(4â²). ⺠The position of the triphosphate group (5â² and not 3â²) on the ribose/deoxyribose ring of the cosubstrate is important for recognition by ANT(4â²). ⺠NTPs with large substituents at the 3â²-position of the ribose ring are not cosubstrates for ANT(4â²). ⺠Nucleotidylation of aminoglycosides results in completely biologically inactive compounds.
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Authors
Vanessa R. Porter, Keith D. Green, Olga E. Zolova, Jacob L. Houghton, Sylvie Garneau-Tsodikova,