| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764047 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠Reporting for the first time that paraoxonase 1 (PON1) efficiently hydrolyzes tabun. ⺠Efficiency of tabun hydrolysis by PON1 was compared to that of sarin and soman. ⺠Demonstrate that hydrolysis of the nerve agents is PON1 specific. ⺠Evaluated retention of PON1 activity and 3-fold more hydrolysis of nerve agents. ⺠PON1 can be used as a universal bioscavenger against nerve agents.
Keywords
PON1CWNAchemical warfare nerve agentp-NPABChECatalytic bioscavengerdiisopropylfluorophosphatebutyrylcholinesteraseDTNBDFP2-HydroxyquinolinePBSTCPOPVDFp-Nitrophenyl acetateSDS–PAGEAChEOrganophosphateAcetylcholinesterasedithionitrobenzoic acidsodium dodecylsulfate polyacrylamide gel electrophoresistabunProphylaxisChemical warfare nerve agentsParaoxonase 1polyvinylidenedifluoride
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Authors
Manojkumar Valiyaveettil, Yonas Alamneh, Lionel Biggemann, Iswarduth Soojhawon, Bhupendra P. Doctor, Madhusoodana P. Nambiar,