| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764073 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠Reactive oxygen species (ROS) are considered to be a factor in the onset of a number of age-associated conditions, including loss of BMD. ⺠Cu,Zn-superoxide dismutase (Sod1) deficient mice have increased ROS, reduced bone mineral density, decreased bending stiffness, and decreased strength compared to WT controls. ⺠Increased ROS caused by the deficiency of Sod1, may be responsible for the changes in BMD and bone mechanics and therefore represent an appropriate model for studying mechanisms of age-associated bone loss.
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Authors
Michael J. Smietana, Ellen M. Arruda, John A. Faulkner, Susan V. Brooks, Lisa M. Larkin,