| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764081 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠A human host protein, HMGA1a is involved in specific splice site regulation of HIV-1. ⺠HMGA1a binds a sequence adjacent 5Ⲡsplice site 3 (D3) and induces incomplete pre-mRNA splicing which is necessary for HIV-1 related Vpr mRNA production. ⺠This is the first example of a non-classical splicing factor (non-SR, non-hnRNP factor) to regulate alternative splicing of HIV-1.
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Authors
Chikayuki Tsuruno, Kenji Ohe, Madoka Kuramitsu, Takuya Kohma, Youichi Takahama, Yukio Hamaguchi, Isao Hamaguchi, Kazu Okuma,