| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764089 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠We identify miR-421 as a novel potential regulator of DPC4/Smad4. ⺠The expression levels of miR-421 and DPC4/Smad4 are inversely correlated in human clinical specimens of pancreatic cancer. ⺠Overexpression of miR-421 represses the reporter activities driven by the 3â²-UTR of DPC4/Smad4 and DPC4/Smad4 protein level in pancreatic cancer cell. ⺠Ectopic expression of miR-421 promotes the proliferation and colony formation of pancreatic cancer cell.
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Authors
Jun Hao, Shuyu Zhang, Yingqi Zhou, Cong Liu, Xiangui Hu, Chenghao Shao,