| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764102 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Invadopodia and podosomes are regulated by Arf and Rho family GTP-binding proteins. ⺠Arf regulators, including ASAP1, have been identified in podosome function but Rho regulators have not. ⺠GEF-H1, a Rho family exchange factor, was identified as a binding partner of ASAP1. ⺠GEF-H1opposes the effects of ASAP1 on the formation of podosomes. ⺠A complex of ASAP1 with GEF-H1 regulates podosome dynamics.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yoko Shiba, Paul A. Randazzo,