| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764115 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠We examined the effects of hepatocyte STAT3 signaling during cholestasis in mice. ⺠Hepatocyte STAT3 offered protection from liver injury and fibrogenesis after BDL. ⺠STAT3-dependent soluble factors released from hepatocytes directly suppressed activated HSCs.
Keywords
ECMSTAT3SAAPDGFHSCsαSMATGFβRTPCRALT5-bromo-2-deoxyuridineBDLAlanine aminotransferaseSTATAlpha-smooth muscle actininterleukinAppsBrdUterminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelingTransforming Growth Factor BetaTUNELserum amyloid AHepatic stellate cellsplatelet derived growth factorLiver fibrosisExtracellular matrixSignal transducer and activator of transcriptionwild-typereverse-transcription polymerase chain reactionAcute phase proteinsbile duct ligationGlycoprotein
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Authors
Minoru Shigekawa, Tetsuo Takehara, Takahiro Kodama, Hayato Hikita, Satoshi Shimizu, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi,