| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764125 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠We established LAT1 amino-acid transporter-disrupted DT40 cells. ⺠LAT1-disrupted cells showed slow growth and lost the oncogenicity. ⺠siRNA and mAb inhibited human tumor growth in vitro and in vivo. ⺠LAT1 is a promising target molecule for cancer therapy.
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Authors
Mayumi Ohkawa, Yoshiya Ohno, Kazue Masuko, Akiko Takeuchi, Kentaro Suda, Akihiro Kubo, Rieko Kawahara, Shogo Okazaki, Toshiyuki Tanaka, Hideyuki Saya, Masayuki Seki, Takemi Enomoto, Hideki Yagi, Yoshiyuki Hashimoto, Takashi Masuko,