Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

Article ID	Journal	Published Year	Pages	File Type
10764136	Biochemical and Biophysical Research Communications	2011	6 Pages	PDF

Abstract

âº Epigallocatechin-3-gallate (EGCG) is an ATP-competitive inhibitor of PI3K and mTOR with Ki values around 300Â nM. âº EGCG inhibits cell proliferation and AKT phosphorylation at Ser473 in MDA-MB-231and A549 cells. âº Molecular docking studies show that EGCG binds well to the PI3K kinase domain active site. âº These results suggest another important molecular mechanism for the anticancer activities of EGCG.

Keywords

PI3K EGCG mTOR PDK1 mTORC2 (−)-Epigallocatechin-3-gallate Phosphatidylinositol-3,4,5-Triphosphate PI(3,4,5)P3 adenosine 5′-triphosphate ATP Akt Cancer phosphoinositide-3-kinase Kinase inhibitor mammalian target of rapamycin Mammalian target of rapamycin complex 2