| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764196 | Biochemical and Biophysical Research Communications | 2010 | 4 Pages |
Abstract
⺠Regulatory T cells (Tregs) play a role in the suppression of immune responses. ⺠The most prominent subtypes are natural Tregs (nTregs) and inducible Tregs (iTregs). ⺠The investigators showed that Tregs directly suppress the differentiation of osteoclasts in vitro. ⺠Increasing Tregs number that can protect against TNF-induced bone loss in TNF-transgenic mice and ovariectomy-induced bone loss in FoxP3-transgenic mice.
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Authors
Feng-Lai Yuan, Xia Li, Wei-Guo Lu, Rui-Sheng Xu, Yi-Qing Zhao, Cheng-Wan Li, Jian-Ping Li, Fei-Hu Chen,