| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764217 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠ChREBP silencing enhances glucose-responsive gene expression in MIN6 β-cells. ⺠ChREBP modulation of Pdx-1 gene expression might be indirect. ⺠ChREBP over-expression decreases Pdx-1, MafA, Ins1, Ins2 and GcK mRNA levels in mouse pancreatic islets of Langerhans.
Keywords
HIFcarbohydrate responsive element-binding proteinL-PKL-type pyruvate kinaseMIN6MafAUSFChREBPPDX-1ARNTGCKFASSREBP-1cGFPSmall interfering RNAsiRNAPancreatic β-cellsaryl hydrocarbon receptor nuclear translocatorfatty acid synthaseinsulinchromatin immunoprecipitationGene expressionIslets of LangerhansUpstream stimulatory factorHypoxia Inducible Factorgreen fluorescent proteinCHiPChoREGlucokinase
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Authors
Gabriela da Silva Xavier, Gao Sun, Qingwen Qian, Guy A. Rutter, Isabelle Leclerc,