| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764230 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
⺠Saturated FFA (palmitate) induces inflammation and apoptosis of renal tubular cells. ⺠Palmitate is incorporated into DAG, which activates PKCθ in renal tubular cells. ⺠Unsaturated FFAs, oleate and EPA, inhibit palmitate-induced renal tubular damages. ⺠Unsaturated FFAs convert DAG to TG, which inhibits palmitate-induced PKCθ activity. âºDgat2 is required for oleate- and EPA-mediated renoprotection against lipotoxicity.
Keywords
EPALDSPKCθPUFAsDGATPKCDGAT2SFAMUFAMCP-1FFAHPTECLPSTNFαTLRsEicosapentaenoic acidFree fatty acidsaturated fatty acidPolyunsaturated fatty acidsmonounsaturated fatty acidinflammationtumor necrosis factor-αApoptosisdiacylglycerolDiacylglycerol acyltransferaseDAGLipid dropletslipopolysaccharidemonocyte chemoattractant protein-1Protein kinase CToll-like receptors
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Authors
Mariko Soumura, Shinji Kume, Keiji Isshiki, Naoko Takeda, Shin-ichi Araki, Yuki Tanaka, Toshiro Sugimoto, Masami Chin-Kanasaki, Yoshihiko Nishio, Masakazu Haneda, Daisuke Koya, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uzu,