| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764235 | Biochemical and Biophysical Research Communications | 2010 | 8 Pages |
Abstract
⺠To enhance the cell survival of MSCs in ischemic myocardium, MSCs were genetically engineered to overexpress phosphoinositide-3-kinase class II alpha (PI3K-C2α). ⺠PI3K-C2α increased the cell viability and the levels of survival-related phosphorylation of MSCs. ⺠The level of apoptotic proteins downregulated and the number of PI positive cells decreased in PI3K-C2α-MSCs. ⺠PI3K-C2α-MSCs were examined in the infarcted heart whether implanted cells have changed morphologically (various staining) and functionally (millar catheterization).
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Authors
Lucy Youngmin Eun, Byeong-Wook Song, Min-Ji Cha, Heesang Song, Il-Kwon Kim, Eunmi Choi, Woochul Chang, Soyeon Lim, Eun Ju Choi, Onju Ham, Se-Yeon Lee, Ki Hyun Byun, Yangsoo Jang, Ki-Chul Hwang,