| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764241 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠AS1535907 represents a novel small-molecule GPR119 agonist that enhances insulin secretion at 16.8 mM glucose in rat islets. ⺠AS1535907 enhances the first phase of insulin secretion at 16.8 mM glucose in isolated perfused rat pancreas. ⺠AS1535907 reduces blood glucose levels due to the rapid secretion on insulin secretion following oral glucose loading in diabetic db/db mice.
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Authors
Shigeru Yoshida, Takahide Ohishi, Tetsuo Matsui, Hirotsugu Tanaka, Hiroyuki Oshima, Yasuhiro Yonetoku, Masayuki Shibasaki,