| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764265 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
⺠A neurotoxin, MPTP, induces activation of caspase-3 and apoptosis in the substantia nigra in the early stage of the development of Parkinson's disease in mice. ⶠGene disruption of caspase-3 blocks MPTP-induced apoptosis of dopamine neurons in mice. ⶠCaspase-3-deficient mice are protected from MPTP-induced Parkinson's disease. ⶠActivation of caspase-3 is required for apoptosis of dopamine neurons and progression of Parkinson's disease induced by MPTP administration in mice.
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Authors
Marina Yamada, Kotaro Kida, Willington Amutuhaire, Fumito Ichinose, Masao Kaneki,