| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764278 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠The new HNO donor, 1-nitrosocyclohexyl acetate (NCA), increases sarcomere shortening in a concentration-dependent manner in normal and pathological ventricular myocytes. ⺠NCA increases sarcomere shortening to an approximately twofold greater extent than Ca2+-transients. ⺠NCA does not affect diastolic Ca2+ or SR Ca2+ content. ⺠NCA increases force of contraction in isolated hearts.
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Authors
Ali El-Armouche, Azadeh Wahab, Katrin Wittköpper, Thomas Schulze, Felix Böttcher, Lutz Pohlmann, S. Bruce King, Jenna F. DuMond, Christian Gerloff, Rainer H. Böger, Thomas Eschenhagen, Lucie Carrier, Sonia Donzelli,