| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764283 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠PRIMA-1 induces a nucleolar redistribution of mutant p53 in breast cancer cells. ⺠PRIMA-1 does not affect the level of mutant p53 phosphorylated at S392 and S15. ⺠PRIMA-1 triggers mutant p53 degradation via ubiquitylation in MDA-MB-231. ⺠Low level of mutant p53 sensitizes MDA-MB-231 breast cancer cells to PRIMA-1.
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Authors
Debora Russo, Laura Ottaggio, Ilaria Penna, Giorgia Foggetti, Gilberto Fronza, Alberto Inga, Paola Menichini,