| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764332 | Biochemical and Biophysical Research Communications | 2010 | 7 Pages |
Abstract
⺠We studied the influences of dietary LC-PUFAs in dams (C57BL/6 and C3H/He) on eye morphogenesis and organogenesis of their pups. ⺠C57BL/6 dams fed LC-PUFA-enriched diet displayed a higher incidence of eye abnormalities than those from dams fed LC-PUFA-poor diet. ⺠The effects of LC-PUFAs on eye anomalies were evident only in the female pups of C57BL/6 inbred mice. ⺠These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. ⺠Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction.
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Authors
Motoko Maekawa, Yoshimi Iwayama, Akiko Watanabe, Yayoi Nozaki, Tetsuo Ohnishi, Hisako Ohba, Manabu Toyoshima, Kei Hamazaki, Noriko Osumi, Jun Aruga, Takeo Yoshikawa,