| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764345 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠We generated vacuolar protein sorting (Vps) 26b knock mice. ⺠Vps26b-deficient mice showed a severe reduction of Vps35 protein levels and lacked the Vps26b-Vps29-Vps35 retromer complex. ⺠The levels of sortilin is increased approximately 20% in the Vps26b-deficient mice. ⺠More p75NTR was immunoprecipitated with sortilin antibody from Vps26bâ/â brains than from wild-type brains. ⺠Vps26b-Vps29-Vps35 retromer complex is implicated in the transport of sortilin from endosomes to the trans-Golgi network (TGN).
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Authors
Ekyune Kim, Youngjeon Lee, Hyun-Ju Lee, Ji Su Kim, Bong-Seok Song, Jae-Won Huh, Sang-Rae Lee, Sun-Uk Kim, Sang-Hyun Kim, Yonggeun Hong, Insop Shim, Kyu-Tae Chang,