| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764347 | Biochemical and Biophysical Research Communications | 2010 | 6 Pages |
Abstract
⺠A novel GLP-1 gene therapy utilizing a strategy involving site-specific genome integration. ⺠AAVS1 locus of human chromosome 19 has been considered as a safe integration site for gene therapy. ⺠The plasmid-AAVS1 specific integration yields GLP-1 production in mice carrying AAVS1. ⺠This therapy improves metabolic status in the AAVS1 mice on high-fat diet feeding. ⺠This approach shows no detrimental effects and thus may find clinical applications.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Rui Liu, Yiming Li, Renmin Hu, Tianru Jin, Shanshan Deng, Wang Liang, Nina Zhang, Jinzhong Chen, Gerald J Prud'homme, William W Jia, Duan Ma, Qinghua Wang,