Article ID Journal Published Year Pages File Type
10764349 Biochemical and Biophysical Research Communications 2010 6 Pages PDF
Abstract
► IL-6 induces MMP-1, MMP-3 and MMP-13 via ERK1/2 signaling in chondrocytes. ► HA inhibits MMP induction by IL-6. ► HA induces MKP-1, negative regulator of ERK1/2. ► MKP-1 induced by HA blocks production of MMP.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1
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