| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764379 | Biochemical and Biophysical Research Communications | 2010 | 5 Pages |
Abstract
⺠ATDC5 cells express Osx that is an essential regulator of osteoblast differentiation. ⺠Osx gene silencing down-regulated expression of chondrogenic factors such Sox9, Dlx5 and ALP. ⺠BMP2 stimulation rescued Osx expression accompanied by up-regulation of ALP and Dlx5 in Osx gene silencing cells. ⺠Osx gene silencing inhibited the expression of the hypertrophic chondrocyte marker gene, type X collagen in insulin treated cells.
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Authors
Kazuki Omoteyama, Minoru Takagi,