| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764394 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Centchroman (CC) inhibits cellular proliferation in HNSCC cells through the dual inhibition of PI3/mTOR pathway. ⺠CC treatment also inhibits STAT3 activation and alters expression of proteins involved in cell cycle regulation and DNA repair response in HNSCC cells. ⺠CC exhibits anti-proliferative activity in a variety of non-HNSCC cancer cell lines and is devoid of cytotoxicity to normal cell types of diverse origins.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Vikas Kumar Srivastava, Rishi Kumar Gara, M.L.B. Bhatt, D.P. Sahu, Durga Prasad Mishra,