| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764396 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Treatment of macrophages with LPS activates Nrf2, a transcription factor that down-regulates inflammation, and induces the expression of Nrf2-dependent genes. ⺠Silencing of Nrf2 by siRNA diminishes the expression of Nrf2-dependent genes. ⺠Nrf2 activation in response to LPS is mediated by MyD88 signaling without the aid of reactive oxidant species. ⺠Nrf2 activation by LPS could be a mechanism by which inflammation is self-limited.
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Authors
Kyun Ha Kim, Ji Hyo Lyu, Sung Tae Koo, Sei-Ryang Oh, Hyeong-Kyu Lee, Kyung-Seop Ahn, Ruxana T. Sadikot, Myungsoo Joo,