Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10764410 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠The nature of reactive oxygen species with associated signaling was investigated in H9c2 cardiomyoblasts exposed to cholesterol secoaldehyde (ChSeco). ⺠Both catalase and deferoxamine, which decreased intracellular reactive oxygen species, were found to alleviate the ChSeco-induced cytotoxicity. ⺠ChSeco-treated cardiomyoblasts exhibited a significant decrease in catalase activity and a marked increase in lipid peroxidation. ⺠Pre-treatment of cardiomyoblasts with SB 203580 or MEK1/2 inhibitor offered protection against the ChSeco-induced cytotoxicity. ⺠These results, together with increased p-SAPK/JNK and p38 protein expression, are consistent with H2O2-dependent MAPK signaling in ChSeco-induced cytotoxicity.
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Authors
Laura Laynes, Achuthan C. Raghavamenon, Oswald D'Auvergne, Vinitha Achuthan, Rao M. Uppu,