| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764423 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Ibandronate significantly promote the proliferation of PDLSC cells. ⺠Ibandronate enhanced the expression of ALP, COL-1, OPG, OCN, Runx2. ⺠The expression of a class of miRNAs, e.g., miR-18a, miR-133a, miR-141 and miR-19a, was significantly modified in PDLSC cells cultured with ibandronate. ⺠Ibandronate regulates the expression of diverse bone formation-related genes via miRNAs in PDLSCs. ⺠Ibandronate can suppress the activity of osteoclast while promoting the proliferation of osteoblast by regulating the expression of microRNAs.
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Authors
Qiang Zhou, Zhi-Ning Zhao, Jing-Tao Cheng, Bin Zhang, Jie Xu, Fei Huang, Rui-Ni Zhao, Yong-Jin Chen,