Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10764425 | Biochemical and Biophysical Research Communications | 2011 | 4 Pages |
Abstract
⺠Sanguinarine (SGR) - human telomere (H24) interaction was studied by CD, NMR and time-resolved fluorescence. ⺠SGR exhibits two distinct interactions with H24 in presence of potassium. ⺠Up to about 1:2 M ratio of H24:SGR (10 μM H24), two molecules of SGR bind H24. ⺠Beyond 1:2 M ratio, SGR induces a conformational transition in H24 from the physiologically relevant K+-form to the non-canonical Na+-form.
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Authors
Suman Kalyan Pradhan, Dipak Dasgupta, Gautam Basu,