| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764433 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Glycated serum (GS) induced apoptosis in pancreatic β-cells, inhibited the glucose stimulated insulin secretion (GSIS) function in rat islets. ⺠Treatment with GS increased the receptor for AGEs (RAGE) protein production in cultured pancreatic β-cells. ⺠GS treatment also decreased bcl-2 gene expression, followed by mitochondrial swelling, increased cytochrome c release, and caspase activation. ⺠RAGE antibody and knockdown of RAGE reversed the β-cell apoptosis and bcl-2 expression. ⺠Inhibition of RAGE reversed the insulin gene expression, but could not restore the GSIS function in rat islets.
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Authors
Yunxia Zhu, Tingting Shu, Yan Lin, Hongdong Wang, Junwei Yang, Yuguang Shi, Xiao Han,