| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764436 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠A novel class I HDAC inhibitor decreased hepatic PEPCK mRNA and gluconeogenesis. ⺠Inhibition of HDAC decreased PEPCK by reducing HNF4α expression and FoxO1 activity. ⺠siRNA knockdown of HDAC1 in HepG2 cells reduced the expression of PEPCK and HNF4α. ⺠Inhibition of class I HDAC improves glucose homeostasis in HFD mice.
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Authors
Hiroshi Oiso, Noboru Furukawa, Mihoshi Suefuji, Seiya Shimoda, Akihiro Ito, Ryohei Furumai, Junichi Nakagawa, Minoru Yoshida, Norikazu Nishino, Eiichi Araki,