| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764468 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠MED25 and PTOV1 compete for CBP binding through the common PTOV domain. ⺠MED25 increases, whereas PTOV1 decreases CBP binding to RA-responsive chromatin. ⺠MED25 elevates, while PTOV1 suppresses RA-induced transcriptional activity of RAR. ⺠MED25 and PTOV1 are determinants of RA sensitivity critical for cancer therapy.
Keywords
CBPMed25RXRRARRetinoid X receptorβ-galGSTDBDLBDLUCGFPshRNAatRAsmall hairpin RNAall-trans retinoic acidchromatin immunoprecipitationβ-galactosidaseDNA-Binding Domainligand-binding domainCancerluciferaseWestern blottingCREB-binding proteingreen fluorescent proteinCHiPglutathione S-transferaseRetinoic acid receptorNuclear receptor
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Authors
Hye-Sook Youn, Ui-Hyun Park, Eun-Joo Kim, Soo-Jong Um,