| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764493 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Defects in HNF-1B transcription factor affect Mg2+ handling in the distal kidney. ⺠γa- and γb- subunits of the Na+/K+-ATPase colocalize in the distal convoluted tubule of the nephron. ⺠HNF-1B specifically activates γa expression. ⺠HNF-1B mutants have a dominant negative effect on wild type HNF-1B activity. ⺠Defective transcription of γa may promote renal Mg2+ wasting.
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Authors
Silvia Ferrè, Gert Jan C. Veenstra, Rianne Bouwmeester, Joost G.J. Hoenderop, René J.M. Bindels,