| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764529 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠Caloric restriction (CR) reduced the weight of ob/ob mice. ⺠CR reduced ER stress markers such as phosphorylated PERK and eIF2α in ob/ob mice. ⺠CR reduced JNK and IRS-1 serine phosphorylation in ob/ob mice. ⺠CR improved glucose tolerance and hepatic insulin action in ob/ob mice. ⺠Reduction in ER stress by CR was comparable to that by a chemical chaperone PBA.
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Authors
Atsuyuki Tsutsumi, Hiroyuki Motoshima, Tatsuya Kondo, Shuji Kawasaki, Takeshi Matsumura, Satoko Hanatani, Motoyuki Igata, Norio Ishii, Hiroyuki Kinoshita, Junji Kawashima, Kayo Taketa, Noboru Furukawa, Kaku Tsuruzoe, Takeshi Nishikawa, Eiichi Araki,