| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764535 | Biochemical and Biophysical Research Communications | 2011 | 8 Pages |
Abstract
⺠ROS and mitochondrial dysfunction have been described as the central part of the pathogenesis of diabetic retinopathy. ⺠SS31 is a novel class of mitochondria-targeted antioxidant peptide, and it can scavenge H2O2 and ONOO- and inhibit lipid peroxidation. ⺠In our study, we provided the first evidence that SS31 could attenuate the high glucose-induced injuries on HRECs by reducing ROS production, stabilize mitochondrial potential and decrease the release of cytochrome c from mitochondria to cytoplasm. ⺠In addition, SS31 also could decrease the expression of caspase-3 and increase the expression of Trx-2. ⺠Our study suggests that SS31 has excellent potential as a new therapeutic for the treatment of diabetic retinopathy and other oxidative stress related diseases.
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Authors
Jianqiao Li, Xiaoyun Chen, Wei Xiao, Wei Ma, Tao Li, Juan Huang, Xialin Liu, Xiaoling Liang, Shibo Tang, Yan Luo,