Voltage-dependent anion channel involved in the mitochondrial calcium cycle of cell lines carrying the mitochondrial DNA A4263G mutation

► We first reported a Chinese family carrying tRNAIle A4263G mutation associated with hypertension. We did further investigations on the mechanism of mtDNA mutation contributing to hypertension. ► We found the mitochondrial Ca2+ concentration and membrane potential (ΔΨm) of the cell lines carrying this mutation was lower than that of the control group. ► The difference between mutated cell lines and control cells was diminished by Cyclosporin A (VDAC blocker). So VDAC is involved in the increase of mitochondrial permeability to Ca2+ and decrease of mitochondrial membrane potential of the cell lines carrying this mutations.