| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764541 | Biochemical and Biophysical Research Communications | 2011 | 6 Pages |
Abstract
⺠An activation domain of CAC gene promoter contains FOXA and Sp1 active sites. ⺠This domain confers high LUC transgene activity in HepG2 and low activity in HEK293 and SK-N-SH cells. ⺠FOXA mutations decrease LUC activity in HepG2 but not in HEK293 and SK-N-SH cells not containing FOXA1-3 transcription factors. ⺠FOXA2 and Sp1 in HepG2 and only Sp1 in HEK293 and SK-N-SH cells are bound to the CAC promoter. ⺠Our results highlight new mechanisms of CAC gene expression and explain differences in CAC levels between hepatic and non-hepatic cells.
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Authors
Paolo Convertini, Vittoria Infantino, Faustino Bisaccia, Ferdinando Palmieri, Vito Iacobazzi,