Article ID Journal Published Year Pages File Type
10764555 Biochemical and Biophysical Research Communications 2011 7 Pages PDF
Abstract
► ALDH2 is an MDA-modified protein in old rat kidney tissues. ► AMPK associates with ALDH2 and triggers the nuclear localization of ALDH2. ► ALDH2 serves as a general transcriptional repressor by associating with HDACs. ► MDA inhibits the AMPK-mediated translocation of ALDH2 and its repression activity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription
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