| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764601 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠VCAM-1 expression was markedly decreased during long-term culture of MSCs. ⺠The VCAM-1 expression was restored by applying hyaluronan to the culture. ⺠Hyaluronan level was also greatly reduced in the senescent MSCs, mainly due to decreased expression of hyaluronan synthases. ⺠Knock-down of hyaluronan synthase genes resulted in decreased expression of VCAM-1. ⺠Hyaluronan-supplemented culture of MSC will compensate the adverse effects induced by its decreased synthesis.
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Authors
Eun Mi Jung, Ohsuk Kwon, Ki-Sun Kwon, Yee Sook Cho, Sang Ki Rhee, Jeong-Ki Min, Doo-Byoung Oh,