| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10764634 | Biochemical and Biophysical Research Communications | 2011 | 7 Pages |
Abstract
⺠Protective effects of pioglitazone (thiazolidine derivatives), alogliptin (dipeptidyl peptidase 4 inhibitor) and insulin on β-cell in diabetic db/db mice. ⺠Islet mass and insulin content were preserved in pioglitazone, pioglitazone + alogliptin or insulin groups. ⺠Pioglitazone + alogliptin and insulin preserved normal insulin secretion, although pioglitazone mono therapy improved partially. ⺠Expression level of MafA and GLP-1R was preserved by pioglitazone or insulin therapy.
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Authors
Satoshi Kawashima, Taka-aki Matsuoka, Hideaki Kaneto, Yoshihiro Tochino, Ken Kato, Kaoru Yamamoto, Tsunehiko Yamamoto, Munehide Matsuhisa, Iichiro Shimomura,