Identification and biological activities of a new antiangiogenic small molecule that suppresses mitochondrial reactive oxygen species

► YCG063 was screened as a new angiogenesis inhibitor which suppresses mitochondrial ROS generation in a phenotypic cell-based screening of a small molecule-focused library. ► The compound inhibited in vitro and in vivo angiogenesis in a dose-dependent manner. ► This new small molecule tool will provide a basis for a better understanding of angiogenesis driven under hypoxic conditions.